THE RELATION BETWEEN THE LEVEL OF URIC ACID AND REMODELING OF THE MYOCARDIUM AND CAROTID ARTERIES IN PATIENTS OF THE HOSPITAL OF THE MEDICAL CENTER OF THE ADMINISTRATIVE DEPARTMENT OF THE PRESIDENT OF THE REPUBLIC OF KAZAKHSTAN

Abstract

The aim of the study was to establish and evaluate the character of associations between the level of uric acid (UA) and myocardial remodeling of (MR) and carotid remodeling (CR) in patients with arterial hypertension (AH). The authors used secondary data obtained from the hospital information database. Patients were divided into groups by sex, age, no remodeling, carotid remodeling (CR), myocardial remodeling (MR), and carotid and myocardial remodeling (CR and MR). The analysis showed that with aging, the share of patients without remodeling decreased (38.4% of patients younger than 45 years old vs 14.3% of patients aged 45 and older. The share of patients with RCA (38.4% vs 51.0%) and the share of patients with RM and RCA (11.15% vs 27.3%) increased, and the share of patients with RM decreased from 12.1% to 7.5%. One-sided ANOVA analysis for the evaluation of the levels of UA in groups divided by the parameter of remodeling showed that the level of UA was significantly different, F (3, 374) = 2.895, р <0.05. In the group of patients that did not have remodeling, it was 341.84 ± 73.46; in the group with CR, it was 339.7 ± 78.69; in the group with MR, it was 343.39 ± 84.36; and in the group with CR and MR, it was 367.4 ± 71.18. Tukey’s test showed that an increase in the level of UA in the group of patients with MR and CR (27.73, 95% CI (from 52.81 to 265)) was statistically significant (р <0.05). The results of the present study indicate that, in the studied population, MR was performed earlier, and CR – later (the number of such patients was higher). Also, probably, the level of UA was not associated with MR and CR. However, it was significantly higher in the group of patients with MR and CR, which could be associated with the progressing of AH.