SEARCH FOR POLYMORPHIC VARIANTS OF GENES ASSOCIATED WITH TYPE 2 DIABETES IN INDIVIDUALS OF THE KAZAKH POPULATION

Abstract

The association of single nucleotide polymorphisms (SNPs) with type 2 diabetes mellitus (T2DM) has been the subject of numerous genetic studies in European, some Asian and African American populations. The present study was performed to find out polymorphic variants of genes associated with type 2 diabetes in individuals of the Kazakh population. SNP candidates were genotyped in 139 patients with type 2 diabetes and 100 healthy controls with no evidence of the disease. Of the 25 previously tested SNPs, eight rs17584499 rs7903146 rs7756992 rs7754840 rs 2237892 rs4712524 (P <0.001), rs1333051 and rs7901695 (P <0.01) statistically significant polymorphic genetic variants were identified. Besides, seven of the tested SNPs had an odds ratio (OR) 1.7 - 2.6, (P <0.05), suggesting that these variants could potentially be used in the Kazakh population for prognostic T2DM testing.